Presentation
I obtained a PhD degree in Molecular Biomedicine at the Spanish National Cancer Research Centre (Madrid, Spain), where I studied the role of cell competition in carcinogenesis using chemical and genetic mouse models of cancer. In 2011, I was awarded a Marie Curie postdoctoral fellowship within the EuroCancerStemCell training network. It allowed me to carry out a collaborative research project at Xentech (Evry, France), as a result of which I identified a novel marker of chemotherapy-resistant human breast cancer cells. From 2013 to 2017, I worked as a postdoctoral researcher at the Viral Genomics and Vaccination Unit in Pasteur Institute (Paris, France), where I developed a genome-wide screening assay for identification of Flavivirus host cell replication factors.
In 2018, I was recruited as a postdoctoral researcher at the laboratory of Genetic Skin Diseases at Imagine Institute in order to characterize a mouse model of Netherton syndrome and to optimize it for pre-clinical testing of novel candidate therapeutics. Since then, I have also been involved in other projects, which aim to decipher the molecular mechanisms of Netherton syndrome using both mouse models and patient samples.
Resources & publications
-
Journal (source)J. Invest. Dermatol.
A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia.
-
Journal (source)Br. J. Dermatol.
EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv...
-
Journal (source)Br. J. Dermatol.
EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv...
-
Journal (source)J. Invest. Dermatol.
Mutations in PERP Cause Dominant and Recessive Keratoderma.
-
Journal (source)Mol Ther Nucleic Acids
Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Usin...
-
Journal (source)Sci Transl Med
APOBEC mutation drives early-onset squamous cell carcinomas in recessive dyst...
-
Journal (source)J. Invest. Dermatol.
Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Reces...
-
Journal (source)J. Am. Acad. Dermatol.
Diacerein orphan drug development for epidermolysis bullosa simplex: A phase ...
-
Journal (source)J. Invest. Dermatol.
Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7)...
-
Journal (source)J. Invest. Dermatol.
Targeted Exon Skipping Restores Type VII Collagen Expression and Anchoring Fi...
-
Journal (source)J. Invest. Dermatol.
Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bull...
-
Journal (source)PLoS Genet.
KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
-
Journal (source)J. Exp. Med.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks...
-
Journal (source)J Allergy Clin Immunol
Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α a...
-
Journal (source)Expert Opin Emerg Drugs
Emerging drugs for the treatment of epidermolysis bullosa.
-
Journal (source)J Invest Dermatol
Drug Repurposing Reveals mTOR Inhibition as a Promising Strategy for Epidermo...